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Spanish second seed Alcaraz led 4-6 7-6 (7-3) 6-0 2-0 when Italy's Musetti, aiming to reach his first major final, was forced to end the match early.
"It's never fair. I want to win but not like this," said Alcaraz.
"When I was serving I started losing a bit of strength on the left leg and it was getting worse and worse," the 23-year-old said.
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